3,704 citations, h-index 21, i10-index 25 (Jan 30 2024)
Students under my supervision are underlined.
Gravel SP*, Ben Khalifa Y, McGuirk S, St-Louis C, Laurin K, Lavallée É, Desbouis S, Amaral F, Benas D, Breton L, Jäger S, St-Pierre J*. PGC-1s Shape Epidermal Physiology by Modulating Keratinocyte Proliferation and Terminal Differentiation. iScience. 2023 Mar 2;26(4):106314. (* co-corresponding authors)
Laurin K, Coutu-Beaudry K, Meribout N, Salazar A, Audet-Walsh E, Gravel SP. Low expression of PGC-1β and other mitochondrial biogenesis modulators in melanoma is associated with growth arrest and the induction of an immunosuppressive gene expression program dependent on MEK and IRF-1. Cancer Lett. 2022 Aug 10;541:215738.
Zadory M, Lopez E, Babity S, Gravel SP, Brambilla D. Current knowledge on tissue distribution of mRNA nanocarriers for therapeutic protein expression. Biomater Sci. 2022 Oct 25;10(21):6077-6115.
Mellal K, Omri S, Mulumba M, Tahiri H, Fortin C, Dorion MF, Pham H, Garcia Ramos Y, Zhang J, Punder S, Joyal JS, Bouchard JF, Sennlaub F, Febbraio M, Hardy P, Gravel SP, Marleau S, Lubell WD, Chemtob S, Ong H. Immunometabolic modulation of retinal inflammation by CD36 ligand. Sci Rep. 2019 Sep 9;9(1):12903.
Hulea L*, Gravel SP*, Morita M*, Cargnello M, Uchenunu O, Im YK, Lehuédé C, Ma EH, Leibovitch M, McLaughlan S, Blouin MJ, Parisotto M, Papavasiliou V, Lavoie C, Larsson O, Ohh M, Ferreira T, Greenwood C, Bridon G, Avizonis D, Ferbeyre G, Siegel P, Jones RG, Muller W, Ursini-Siegel J, St-Pierre J, Pollak M, Topisirovic I. Translational and HIF-1α-Dependent Metabolic Reprogramming Underpin Metabolic Plasticity and Responses to Kinase Inhibitors and Biguanides. Cell Metab. 2018 Sep 17. pii: S1550-4131(18)30566-7. doi: 10.1016/j.cmet.2018.09.001.
Shamalnasab M, Gravel SP, St-Pierre J, Breton L, Jäger S, Aguilaniu H. A salicylic acid derivative extends the lifespan of Caenorhabditis elegans by activating autophagy and the mitochondrial unfolded protein response. Aging Cell. 2018 Sep 7:e12830. doi: 10.1111/acel.12830.
Poffenberger MC, Metcalfe-Roach A, Aguilar E, Chen J, Hsu BE, Wong AH, Johnson RM, Flynn B, Samborska B, Ma EH, Gravel SP, Tonelli L, Devorkin L, Kim P, Hall A, Izreig S, Loginicheva E, Beauchemin N, Siegel PM, Artyomov MN, Lum JJ, Zogopoulos G, Blagih J, Jones RG. LKB1 deficiency in T cells promotes the development of gastrointestinal polyposis. Science. 2018 Jul 27;361(6400):406-411. doi: 10.1126/science.aan3975.
Thivierge C, Tseng HW, Mayya VK, Lussier C, Gravel SP, Duchaine TF. Alternative polyadenylation confers Pten mRNAs stability and resistance to microRNAs. Nucleic Acids Research. 2018 Nov 2;46(19):10340-10352. doi: 10.1093/nar/gky666.
Im YK*, Najyb O*, Gravel SP, McGuirk S, Ahn R, Avizonis DZ, Chénard V, Sabourin V, Hudson J, Pawson T, Topisirovic I, Pollak M, St-Pierre J, Ursini-Siegel J. Interplay between ShcA Signaling and PGC-1α Triggers Targetable Metabolic Vulnerabilities in Breast Cancer. Cancer Res. 2018 Sep 1;78(17):4826-4838. doi: 10.1158/0008-5472.CAN-17-3696. Epub 2018 Jun 21.
Gravel SP. Deciphering the dichotomous effect of PGC-1α on tumorigenesis and metastasis.Topic: Cancer – A Spectrum of Diseases at the Crossroad Between Cell Signaling, (Epi)genetics, and the Microenvironment. Frontiers in Oncology . 2018 Mar 23;8:75. doi: 10.3389/fonc.2018.00075. eCollection (review)
Houles T, Gravel SP, Lavoie G, Shin S, Savall M, Méant A, Grondin B, Gaboury L, Yoon SO, St-Pierre J, Roux PP. RSK Regulates PFK-2 Activity to Promote Metabolic Rewiring in Melanoma. Cancer Res. 2018 Feb 12. pii: canres.2215.2017. doi: 10.1158/0008-5472.CAN-17-2215. [Epub ahead of print] PubMed PMID: 29440170.
Rabinovitch RC, Samborska B, Faubert B, Ma EH, Gravel SP, Andrzejewski S, Raissi TC, Pause A, St-Pierre J, Jones RG. AMPK Maintains Cellular Metabolic Homeostasis through Regulation of Mitochondrial Reactive Oxygen Species. Cell Rep. 2017 Oct 3;21(1):1-9. doi: 10.1016/j.celrep.2017.09.026. PubMed PMID: 28978464.
Uetani N, Hardy S, Gravel SP, Kiessling S, Pietrobon A, Wong NN, Chénard V, Cermakian N, St-Pierre J, Tremblay ML. PRL2 links magnesium flux and sex-dependent circadian metabolic rhythms. JCI Insight. 2017 Jul 6;2(13). pii: 91722. doi: 10.1172/jci.insight.91722. [Epub ahead of print] PubMed PMID: 28679948; PubMed Central PMCID: PMC5499375.
Gravel SP, Avizonis D, St-Pierre J. Metabolomics Analyses of Cancer Cells in Controlled Microenvironments. Methods Mol Biol. 2016;1458:273-90. doi: 10.1007/978-1-4939-3801-8_20. PubMed PMID: 27581029.
Deblois G, Smith HW, Tam IS, Gravel SP, Caron M, Savage P, Labbé DP, Bégin LR, Tremblay ML, Park M, Bourque G, St-Pierre J, Muller WJ, Giguère V. ERRα mediates metabolic adaptations driving lapatinib resistance in breast cancer. Nat Commun. 2016 Jul 12;7:12156. doi: 10.1038/ncomms12156. PubMed PMID: 27402251; PubMed Central PMCID: PMC4945959.
Gandin V*, Masvidal L*, Hulea L*, Gravel SP, Cargnello M, McLaughlan S, Cai Y, Balanathan P, Morita M, Rajakumar A, Furic L, Pollak M, Porco JA Jr, St-Pierre J, Pelletier J, Larsson O, Topisirovic I. nanoCAGE reveals 5' UTR features that define specific modes of translation of functionally related MTOR-sensitive mRNAs. Genome Res. 2016 May;26(5):636-48. doi: 10.1101/gr.197566.115. Epub 2016 Mar 16. PubMed PMID: 26984228; PubMed Central PMCID: PMC4864462.
Audet-Walsh É*, Papadopoli DJ*, Gravel SP, Yee T, Bridon G, Caron M, Bourque G, Giguère V, St-Pierre J. The PGC-1α/ERRα Axis Represses One-Carbon Metabolism and Promotes Sensitivity to Anti-folate Therapy in Breast Cancer. Cell Rep. 2016 Feb 2;14(4):920-931. doi: 10.1016/j.celrep.2015.12.086. Epub 2016 Jan 21. PubMed PMID: 26804918.
Morita M*, Gravel SP*, Hulea L*, Larsson O, Pollak M, St-Pierre J, Topisirovic I. mTOR coordinates protein synthesis, mitochondrial activity and proliferation. Cell Cycle. 2015;14(4):473-80. doi: 10.4161/15384101.2014.991572. Review. PubMed PMID: 25590164; PubMed Central PMCID: PMC4615141.
Gravel SP*, Hulea L*, Toban N*, Birman E, Blouin MJ, Zakikhani M, Zhao Y, Topisirovic I, St-Pierre J, Pollak M. Serine deprivation enhances antineoplastic activity of biguanides. Cancer Res. 2014 Dec 15;74(24):7521-33. doi: 10.1158/0008-5472.CAN-14-2643-T. Epub 2014 Nov 6. PubMed PMID: 25377470.
Andrzejewski S, Gravel SP, Pollak M, St-Pierre J. Metformin directly acts on mitochondria to alter cellular bioenergetics. Cancer Metab. 2014 Aug 28;2:12. doi: 10.1186/2049-3002-2-12. eCollection 2014. PubMed PMID: 25184038; PubMed Central PMCID: PMC4147388.
Gravel SP*, Andrzejewski S*, Avizonis D, St-Pierre J. Stable isotope tracer analysis in isolated mitochondria from mammalian systems. Metabolites. 2014 Apr 10;4(2):166-83. doi: 10.3390/metabo4020166. PubMed PMID: 24957021; PubMed Central PMCID: PMC4101501.
Mamer O*, Gravel SP*, Choinière L, Chénard V, St-Pierre J, Avizonis D. The complete targeted profile of the organic acid intermediates of the citric acid cycle using a single stable isotope dilution analysis, sodium borodeuteride reduction and selected ion monitoring GC/MS. Metabolomics. 2013;9(5):1019-1030. Epub 2013 Apr 17. PubMed PMID: 24348278; PubMed Central PMCID: PMC3855487.
McGuirk S*, Gravel SP*, Deblois G, Papadopoli DJ, Faubert B, Wegner A, Hiller K, Avizonis D, Akavia UD, Jones RG, Giguère V, St-Pierre J. PGC-1α supports glutamine metabolism in breast cancer. Cancer Metab. 2013 Dec 5;1(1):22. doi: 10.1186/2049-3002-1-22. PubMed PMID: 24304688; PubMed Central PMCID: PMC4178216.
Morita M, Gravel SP, Chénard V, Sikström K, Zheng L, Alain T, Gandin V, Avizonis D, Arguello M, Zakaria C, McLaughlan S, Nouet Y, Pause A, Pollak M, Gottlieb E, Larsson O, St-Pierre J, Topisirovic I, Sonenberg N. mTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translational regulation. Cell Metab. 2013 Nov 5;18(5):698-711. doi: 10.1016/j.cmet.2013.10.001. PubMed PMID: 24206664.
Clément JF, Bibeau-Poirier A, Gravel SP, Grandvaux N, Bonneil E, Thibault P, Meloche S, Servant MJ. Phosphorylation of IRF-3 on Ser 339 generates a hyperactive form of IRF-3 through regulation of dimerization and CBP association. J Virol. 2008 Apr;82(8):3984-96. doi: 10.1128/JVI.02526-07. Epub 2008 Feb 13. PubMed PMID: 18272581; PubMed Central PMCID: PMC2292984.
Bibeau-Poirier A, Gravel SP, Clément JF, Rolland S, Rodier G, Coulombe P, Hiscott J, Grandvaux N, Meloche S, Servant MJ. Involvement of the IkappaB kinase (IKK)-related kinases tank-binding kinase 1/IKKi and cullin-based ubiquitin ligases in IFN regulatory factor-3 degradation. J Immunol. 2006 Oct 15;177(8):5059-67. Erratum in: J Immunol. 2006 Dec 15;177(12):8878-9. PubMed PMID: 17015689.
Douillette A*, Bibeau-Poirier A*, Gravel SP*, Clément JF, Chénard V, Moreau P, Servant MJ. The proinflammatory actions of angiotensin II are dependent on p65 phosphorylation by the IkappaB kinase complex. J Biol Chem. 2006 May 12;281(19):13275-84. Epub 2006 Mar 2. PubMed PMID: 16513650.
Gravel SP, Servant MJ. Roles of an IkappaB kinase-related pathway in human cytomegalovirus-infected vascular smooth muscle cells: a molecular link in pathogen-induced proatherosclerotic conditions. J Biol Chem. 2005 Mar 4;280(9):7477-86. Epub 2004 Dec 24. PubMed PMID: 15619605.
Students under my supervision are underlined.
Gravel SP*, Ben Khalifa Y, McGuirk S, St-Louis C, Laurin K, Lavallée É, Desbouis S, Amaral F, Benas D, Breton L, Jäger S, St-Pierre J*. PGC-1s Shape Epidermal Physiology by Modulating Keratinocyte Proliferation and Terminal Differentiation. iScience. 2023 Mar 2;26(4):106314. (* co-corresponding authors)
Laurin K, Coutu-Beaudry K, Meribout N, Salazar A, Audet-Walsh E, Gravel SP. Low expression of PGC-1β and other mitochondrial biogenesis modulators in melanoma is associated with growth arrest and the induction of an immunosuppressive gene expression program dependent on MEK and IRF-1. Cancer Lett. 2022 Aug 10;541:215738.
Zadory M, Lopez E, Babity S, Gravel SP, Brambilla D. Current knowledge on tissue distribution of mRNA nanocarriers for therapeutic protein expression. Biomater Sci. 2022 Oct 25;10(21):6077-6115.
Mellal K, Omri S, Mulumba M, Tahiri H, Fortin C, Dorion MF, Pham H, Garcia Ramos Y, Zhang J, Punder S, Joyal JS, Bouchard JF, Sennlaub F, Febbraio M, Hardy P, Gravel SP, Marleau S, Lubell WD, Chemtob S, Ong H. Immunometabolic modulation of retinal inflammation by CD36 ligand. Sci Rep. 2019 Sep 9;9(1):12903.
Hulea L*, Gravel SP*, Morita M*, Cargnello M, Uchenunu O, Im YK, Lehuédé C, Ma EH, Leibovitch M, McLaughlan S, Blouin MJ, Parisotto M, Papavasiliou V, Lavoie C, Larsson O, Ohh M, Ferreira T, Greenwood C, Bridon G, Avizonis D, Ferbeyre G, Siegel P, Jones RG, Muller W, Ursini-Siegel J, St-Pierre J, Pollak M, Topisirovic I. Translational and HIF-1α-Dependent Metabolic Reprogramming Underpin Metabolic Plasticity and Responses to Kinase Inhibitors and Biguanides. Cell Metab. 2018 Sep 17. pii: S1550-4131(18)30566-7. doi: 10.1016/j.cmet.2018.09.001.
Shamalnasab M, Gravel SP, St-Pierre J, Breton L, Jäger S, Aguilaniu H. A salicylic acid derivative extends the lifespan of Caenorhabditis elegans by activating autophagy and the mitochondrial unfolded protein response. Aging Cell. 2018 Sep 7:e12830. doi: 10.1111/acel.12830.
Poffenberger MC, Metcalfe-Roach A, Aguilar E, Chen J, Hsu BE, Wong AH, Johnson RM, Flynn B, Samborska B, Ma EH, Gravel SP, Tonelli L, Devorkin L, Kim P, Hall A, Izreig S, Loginicheva E, Beauchemin N, Siegel PM, Artyomov MN, Lum JJ, Zogopoulos G, Blagih J, Jones RG. LKB1 deficiency in T cells promotes the development of gastrointestinal polyposis. Science. 2018 Jul 27;361(6400):406-411. doi: 10.1126/science.aan3975.
Thivierge C, Tseng HW, Mayya VK, Lussier C, Gravel SP, Duchaine TF. Alternative polyadenylation confers Pten mRNAs stability and resistance to microRNAs. Nucleic Acids Research. 2018 Nov 2;46(19):10340-10352. doi: 10.1093/nar/gky666.
Im YK*, Najyb O*, Gravel SP, McGuirk S, Ahn R, Avizonis DZ, Chénard V, Sabourin V, Hudson J, Pawson T, Topisirovic I, Pollak M, St-Pierre J, Ursini-Siegel J. Interplay between ShcA Signaling and PGC-1α Triggers Targetable Metabolic Vulnerabilities in Breast Cancer. Cancer Res. 2018 Sep 1;78(17):4826-4838. doi: 10.1158/0008-5472.CAN-17-3696. Epub 2018 Jun 21.
Gravel SP. Deciphering the dichotomous effect of PGC-1α on tumorigenesis and metastasis.Topic: Cancer – A Spectrum of Diseases at the Crossroad Between Cell Signaling, (Epi)genetics, and the Microenvironment. Frontiers in Oncology . 2018 Mar 23;8:75. doi: 10.3389/fonc.2018.00075. eCollection (review)
Houles T, Gravel SP, Lavoie G, Shin S, Savall M, Méant A, Grondin B, Gaboury L, Yoon SO, St-Pierre J, Roux PP. RSK Regulates PFK-2 Activity to Promote Metabolic Rewiring in Melanoma. Cancer Res. 2018 Feb 12. pii: canres.2215.2017. doi: 10.1158/0008-5472.CAN-17-2215. [Epub ahead of print] PubMed PMID: 29440170.
Rabinovitch RC, Samborska B, Faubert B, Ma EH, Gravel SP, Andrzejewski S, Raissi TC, Pause A, St-Pierre J, Jones RG. AMPK Maintains Cellular Metabolic Homeostasis through Regulation of Mitochondrial Reactive Oxygen Species. Cell Rep. 2017 Oct 3;21(1):1-9. doi: 10.1016/j.celrep.2017.09.026. PubMed PMID: 28978464.
Uetani N, Hardy S, Gravel SP, Kiessling S, Pietrobon A, Wong NN, Chénard V, Cermakian N, St-Pierre J, Tremblay ML. PRL2 links magnesium flux and sex-dependent circadian metabolic rhythms. JCI Insight. 2017 Jul 6;2(13). pii: 91722. doi: 10.1172/jci.insight.91722. [Epub ahead of print] PubMed PMID: 28679948; PubMed Central PMCID: PMC5499375.
Gravel SP, Avizonis D, St-Pierre J. Metabolomics Analyses of Cancer Cells in Controlled Microenvironments. Methods Mol Biol. 2016;1458:273-90. doi: 10.1007/978-1-4939-3801-8_20. PubMed PMID: 27581029.
Deblois G, Smith HW, Tam IS, Gravel SP, Caron M, Savage P, Labbé DP, Bégin LR, Tremblay ML, Park M, Bourque G, St-Pierre J, Muller WJ, Giguère V. ERRα mediates metabolic adaptations driving lapatinib resistance in breast cancer. Nat Commun. 2016 Jul 12;7:12156. doi: 10.1038/ncomms12156. PubMed PMID: 27402251; PubMed Central PMCID: PMC4945959.
Gandin V*, Masvidal L*, Hulea L*, Gravel SP, Cargnello M, McLaughlan S, Cai Y, Balanathan P, Morita M, Rajakumar A, Furic L, Pollak M, Porco JA Jr, St-Pierre J, Pelletier J, Larsson O, Topisirovic I. nanoCAGE reveals 5' UTR features that define specific modes of translation of functionally related MTOR-sensitive mRNAs. Genome Res. 2016 May;26(5):636-48. doi: 10.1101/gr.197566.115. Epub 2016 Mar 16. PubMed PMID: 26984228; PubMed Central PMCID: PMC4864462.
Audet-Walsh É*, Papadopoli DJ*, Gravel SP, Yee T, Bridon G, Caron M, Bourque G, Giguère V, St-Pierre J. The PGC-1α/ERRα Axis Represses One-Carbon Metabolism and Promotes Sensitivity to Anti-folate Therapy in Breast Cancer. Cell Rep. 2016 Feb 2;14(4):920-931. doi: 10.1016/j.celrep.2015.12.086. Epub 2016 Jan 21. PubMed PMID: 26804918.
Morita M*, Gravel SP*, Hulea L*, Larsson O, Pollak M, St-Pierre J, Topisirovic I. mTOR coordinates protein synthesis, mitochondrial activity and proliferation. Cell Cycle. 2015;14(4):473-80. doi: 10.4161/15384101.2014.991572. Review. PubMed PMID: 25590164; PubMed Central PMCID: PMC4615141.
Gravel SP*, Hulea L*, Toban N*, Birman E, Blouin MJ, Zakikhani M, Zhao Y, Topisirovic I, St-Pierre J, Pollak M. Serine deprivation enhances antineoplastic activity of biguanides. Cancer Res. 2014 Dec 15;74(24):7521-33. doi: 10.1158/0008-5472.CAN-14-2643-T. Epub 2014 Nov 6. PubMed PMID: 25377470.
Andrzejewski S, Gravel SP, Pollak M, St-Pierre J. Metformin directly acts on mitochondria to alter cellular bioenergetics. Cancer Metab. 2014 Aug 28;2:12. doi: 10.1186/2049-3002-2-12. eCollection 2014. PubMed PMID: 25184038; PubMed Central PMCID: PMC4147388.
Gravel SP*, Andrzejewski S*, Avizonis D, St-Pierre J. Stable isotope tracer analysis in isolated mitochondria from mammalian systems. Metabolites. 2014 Apr 10;4(2):166-83. doi: 10.3390/metabo4020166. PubMed PMID: 24957021; PubMed Central PMCID: PMC4101501.
Mamer O*, Gravel SP*, Choinière L, Chénard V, St-Pierre J, Avizonis D. The complete targeted profile of the organic acid intermediates of the citric acid cycle using a single stable isotope dilution analysis, sodium borodeuteride reduction and selected ion monitoring GC/MS. Metabolomics. 2013;9(5):1019-1030. Epub 2013 Apr 17. PubMed PMID: 24348278; PubMed Central PMCID: PMC3855487.
McGuirk S*, Gravel SP*, Deblois G, Papadopoli DJ, Faubert B, Wegner A, Hiller K, Avizonis D, Akavia UD, Jones RG, Giguère V, St-Pierre J. PGC-1α supports glutamine metabolism in breast cancer. Cancer Metab. 2013 Dec 5;1(1):22. doi: 10.1186/2049-3002-1-22. PubMed PMID: 24304688; PubMed Central PMCID: PMC4178216.
Morita M, Gravel SP, Chénard V, Sikström K, Zheng L, Alain T, Gandin V, Avizonis D, Arguello M, Zakaria C, McLaughlan S, Nouet Y, Pause A, Pollak M, Gottlieb E, Larsson O, St-Pierre J, Topisirovic I, Sonenberg N. mTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translational regulation. Cell Metab. 2013 Nov 5;18(5):698-711. doi: 10.1016/j.cmet.2013.10.001. PubMed PMID: 24206664.
Clément JF, Bibeau-Poirier A, Gravel SP, Grandvaux N, Bonneil E, Thibault P, Meloche S, Servant MJ. Phosphorylation of IRF-3 on Ser 339 generates a hyperactive form of IRF-3 through regulation of dimerization and CBP association. J Virol. 2008 Apr;82(8):3984-96. doi: 10.1128/JVI.02526-07. Epub 2008 Feb 13. PubMed PMID: 18272581; PubMed Central PMCID: PMC2292984.
Bibeau-Poirier A, Gravel SP, Clément JF, Rolland S, Rodier G, Coulombe P, Hiscott J, Grandvaux N, Meloche S, Servant MJ. Involvement of the IkappaB kinase (IKK)-related kinases tank-binding kinase 1/IKKi and cullin-based ubiquitin ligases in IFN regulatory factor-3 degradation. J Immunol. 2006 Oct 15;177(8):5059-67. Erratum in: J Immunol. 2006 Dec 15;177(12):8878-9. PubMed PMID: 17015689.
Douillette A*, Bibeau-Poirier A*, Gravel SP*, Clément JF, Chénard V, Moreau P, Servant MJ. The proinflammatory actions of angiotensin II are dependent on p65 phosphorylation by the IkappaB kinase complex. J Biol Chem. 2006 May 12;281(19):13275-84. Epub 2006 Mar 2. PubMed PMID: 16513650.
Gravel SP, Servant MJ. Roles of an IkappaB kinase-related pathway in human cytomegalovirus-infected vascular smooth muscle cells: a molecular link in pathogen-induced proatherosclerotic conditions. J Biol Chem. 2005 Mar 4;280(9):7477-86. Epub 2004 Dec 24. PubMed PMID: 15619605.